The CMS experiment has a wide program on heavy flavor physics, covering production and decay properties of B hadrons and quarkonia, as well as searches and study of exotic hadrons, and rare decays. In this talk, we present precise measurements of B hadron lifetimes, that are good as or better than previous measurements. Recent measurements of the Lambda_b polarization and angular parameters in Lambda_b ->J/psi Lambda decays are also presented and compared to various theoretical predictions. On the other hand, measurements at 13 TeV of psi(nS) (n=1,2) and Upsilon(nS) (n=1,2,3) production cross sections are shown and compared with theoretical expectations as a function of transverse momentum and rapidity. Finally, we discuss the latests results from CMS on the search for exotic resonances (the controversial X(5568)) in the B_s pi+ mass spectrum.