The OPERA experiment at the Gran Sasso underground laboratory has been designed to study the nu_mu -> nu_tau oscillation in appearance mode in the CNGS neutrino beam. Four nu_tau candidate events have been confirmed so far, using a sub-sample of data from the 2008-2012 runs. Given the number of analysed events and the low background, nu_mu -> nu_tau oscillations have been established with a significance of 4.2 sigma. In the talk we will present results based on an increased sample of scanned emulsion target units (bricks). The nu_tau data analysis will be updated and discussed, with emphasis on the background constraints obtained by using dedicated data-driven control samples. The analysis of the present tau neutrino and electron neutrino samples in the framework of the 3+1 sterile model will be presented. Finally the analysis of the muon charge ratio in the cosmic ray sample will be covered